Fadogia Capsules — OEM Manufacturing with Responsible Dosing Protocols

We've been making Fadogia Agrestis capsules since this ingredient exploded on the market. And we've noticed something: every manufacturer lists specs and MOQ, but nobody talks about the fact that there are zero human clinical trials on this ingredient.

We think that's a problem. So we'll say it directly: Fadogia Agrestis has strong traditional use in West Africa and promising animal research, but the human safety and efficacy data doesn't exist yet. That doesn't mean you shouldn't make it — it means you should make it responsibly.

Here's how we do that.

Product Specifications

What the Research Actually Shows (And Doesn't Show)

Let's be honest about the science, because your customers will find out eventually.

What exists: Three rat studies from the University of Ilorin, Nigeria (Yakubu et al., 2005, 2008, 2009). The 2005 study in the Asian Journal of Andrology showed dose-dependent testosterone increases in rats: 2-fold at 18mg/kg, 3-fold at 50mg/kg, and 6-fold at 100mg/kg. Sexual behavior also improved across all doses.

What also exists: The 2008 follow-up study in the Journal of Ethnopharmacology found that at 50mg/kg and 100mg/kg, rats showed significant adverse alterations in testicular function indices — including changes to seminiferous tubule architecture. At the lowest dose (18mg/kg), effects were largely reversible after washout. The 2009 study in Human & Experimental Toxicology documented liver and kidney cellular toxicity, attributed to quinoline and isoquinoline alkaloids in the plant.

What doesn't exist: A single published human clinical trial. Not one. As of 2026, Fadogia Agrestis remains a supplement with strong market demand and zero human safety data.

We tell you this because we believe brands that acknowledge the evidence gap build more trust than brands that pretend it doesn't exist.

Our Responsible Manufacturing Protocol

Given the evidence situation, here's what we do differently:

1. Conservative Dosing Recommendation

We recommend a maximum of 600mg Fadogia Agrestis extract per day (delivered as 1-2 capsules depending on strength). The rat studies showed that higher doses produced more toxicity without proportionally more testosterone benefit. More is not better here.

2. Cycling Protocol Guidelines

Based on the rat toxicity data showing dose-dependent organ effects, we strongly recommend cycling protocols on all product labels:

• Standard cycle: 8 weeks on, 2 weeks off
• Conservative cycle: 3 weeks on, 1 week off
• The 2008 Yakubu study showed recovery at 18mg/kg after washout, but persistent damage at higher doses — cycling is a precautionary measure

3. Extract Quality Control

Fadogia Agrestis has no standardized extract specification (unlike Tongkat Ali, which has the 2% eurycomanone standard). This means product quality varies wildly across the market.

Our quality protocol:

• Botanical identity verification: HPLC fingerprinting to confirm authentic Fadogia agrestis stem material
• Alkaloid content testing: Quantification of quinoline/isoquinoline alkaloids (the compounds linked to toxicity)
• Heavy metals screening: Every batch tested for Pb, As, Hg, Cd — African-sourced botanicals face unique supply chain challenges
• Microbial limits: Full panel testing per USP <2021>/<2022>
• Extraction method documentation: Aqueous extraction (matching the rat study methodology), not solvent extraction

OEM & Customization Options

Formulation:

• Fadogia Agrestis standalone (300-600mg per capsule)
• Fadogia + Tongkat Ali stack (most popular combination — Tongkat Ali has 20+ human trials supporting testosterone support)
• Fadogia + Tongkat Ali + BioPerine® (enhanced absorption)
• Fadogia + Tongkat Ali + Zinc + Vitamin D3 (complete men's vitality formula)
• Fadogia + Ashwagandha (stress + vitality stack)
• Fadogia + Maca Root (energy + performance)

Capsule Options:

Packaging:

• HDPE bottles (60/90/120 count)
• Amber glass bottles (UV protection)
• Blister packs
• Bulk packaging
• Custom private label design

Labeling:

We recommend including cycling instructions and a responsible use disclaimer on your product label. We can provide template language that meets US/EU supplement labeling requirements.

Why Fadogia Is Often Paired with Tongkat Ali

90% of our Fadogia orders include Tongkat Ali. Here's why this combination makes scientific sense:

The theoretical rationale: Fadogia may stimulate luteinizing hormone (LH) which signals the testes to produce more testosterone, while Tongkat Ali reduces sex hormone-binding globulin (SHBG), freeing up bound testosterone. Together, they theoretically address testosterone from two angles — production and availability.

But we want to be clear: This combination has never been studied in a controlled human trial. The synergy is theoretical, based on extrapolation from animal data and Tongkat Ali's human evidence.

Quality Assurance

• GMP Certified — D-grade cleanroom, 100,000-class environment
• Three-stage testing: Raw material → In-process → Finished product
• Third-party lab verification available for every batch
• Full COA provided: potency, heavy metals, microbial limits, alkaloid content
• Botanical authentication: DNA barcoding + HPLC fingerprinting for every new lot
• Traceability: Full chain of custody from West African source to finished capsule

Why Choose Us

Frequently Asked Questions

Q: What is the recommended dosage for Fadogia Agrestis capsules?

A: Based on the available animal research and market practice, we recommend 300-600mg per day. The rat studies showed dose-dependent effects — but also dose-dependent toxicity. We advise starting at the lower end (300mg) and not exceeding 600mg daily. We also recommend cycling: 8 weeks on, 2 weeks off.

Q: Is Fadogia Agrestis safe for long-term use?

A: There are no published human safety studies on long-term Fadogia Agrestis use. The animal data showed reversible effects at low doses (18mg/kg) but persistent toxicity at higher doses. Based on this, we recommend cycling protocols and periodic blood work monitoring (liver function, kidney function, testosterone levels) for anyone using it regularly.

Q: Why do you recommend pairing Fadogia with Tongkat Ali?

A: Tongkat Ali has 20+ human clinical trials supporting its role in testosterone support, while Fadogia has zero human data. The combination is popular because they theoretically work through different mechanisms (LH stimulation vs. SHBG reduction), but this synergy has never been proven in humans. If your customers want evidence-backed options, Tongkat Ali alone is the stronger choice.

Q: What extract ratio do you use?

A: We offer 10:1 and 20:1 concentration ratios. There is no standardized extract specification for Fadogia Agrestis (unlike Tongkat Ali's 2% eurycomanone standard), so extract ratios are not directly comparable across manufacturers. What matters more is our HPLC fingerprinting and alkaloid testing to ensure consistency between batches.

Q: Can you provide third-party testing certificates?

A: Yes. Every batch comes with a full COA covering potency, heavy metals (Pb, As, Hg, Cd), microbial limits, and alkaloid content. We also provide botanical authentication documentation. Third-party testing through independent labs is available upon request.

Q: What is your MOQ?

A: Minimum order quantity is 100,000 capsules. We can accommodate smaller trial orders for qualified brands — contact us to discuss.

Q: How long is the production lead time?

A: Sample production: 5-7 working days. Mass production: 15-20 working days depending on order volume and packaging customization.

Ready to Start Your Fadogia Project?

Contact us today to discuss your formulation requirements. We'll help you build a responsible, compliant Fadogia Agrestis product with full documentation support.

Our team responds within 24 hours.

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