OEM/ODM
Contact Us
Tel: +86-537-6728868
E-Mail: chairman@sdrxsw.com
WhatsApp/Wetchat: +86 13562721377
Add: No.8 Wucun Industrial Park, Qufu,Shandong,China. 273100
Product Description
Product Specifications
Parameter | Details |
Active Ingredients | Milk Thistle Extract (Silymarin 80%), NAC, TUDCA, Turmeric Extract, Artichoke Leaf, Dandelion Root, Glutathione (reduced), Alpha-Lipoic Acid |
Dosage Strength | Customizable per formula; silymarin 140-600mg, NAC 300-600mg, TUDCA 250-500mg per serving typical |
Capsule Type | Hard capsule (gelatin / HPMC vegan) |
Capsule Size | Size 00, 0, 1, 2, 3 available |
Shelf Life | 24-36 months (depends on formulation and packaging) |
Certifications | ISO9001, ISO22000, FSSC22000, GMP, FDA-registered, HALAL, REACH, ECOCERT |
Annual Capacity | 2 billion capsules/tablets |
MOQ | 100,000 capsules |
Customization Options
Size: Size 00 through 3 — selected based on fill weight needed for your target dosage
Shell Type: Gelatin (bovine/porcine) or HPMC vegetarian — both compatible with liver detox formulations
Color: Clear, opaque, dual-tone, or custom color matching
Packaging: Bulk bottles, blister packs, sachets, or custom retail packaging
Formula: Full OEM/ODM — we develop custom formulations based on your target market, positioning, and regulatory requirements
The Real Challenge: Bioavailability, Not Ingredient Count
The liver supplement market is crowded with "more is better" thinking. A typical competitor formula lists 20 ingredients on the label, each at minimal effective doses. But research consistently shows that the bottleneck in liver support supplementation isn't ingredient selection — it's absorption.
Why Standard Extracts Fall Short
Ingredient | Common Form | Bioavailability Problem |
Silymarin | Standard 80% extract | Oral bioavailability ~0.45%; poor water solubility (50-430 μg/mL), extensive first-pass metabolism |
Curcumin | 95% curcuminoids | Rapidly metabolized and eliminated; minimal systemic exposure without enhancement |
Glutathione | Oral reduced GSH | Broken down by intestinal gamma-glutamyl transpeptidase before absorption |
NAC | Standard powder | Better absorbed than GSH, but still subject to significant first-pass loss |
How We Address This
1. Phytosome-Grade Silymarin Option
We offer silymarin in phytosome form (silymarin bound to phosphatidylcholine), which research shows can improve absorption by up to 10x compared to standard extract. In a clinical trial, phytosomal silymarin reduced ALT levels by 68% in NAFLD subjects — compared to marginal results with standard silymarin (Current Pharmaceutical Design, 2025).
2. Reduced (Active) Glutathione with Enteric Protection
For formulas including glutathione, we use reduced L-glutathione and can apply enteric coating technology to protect it from gastric degradation, improving the fraction that reaches the small intestine intact.
3. Strategic Ingredient Pairing
Some ingredients enhance each other's absorption. For example, piperine (black pepper extract) at 5-10mg can improve curcumin bioavailability by up to 2,000%. We design formulas where ingredients work together, not against each other.
4. TUDCA as a Bile Acid Optimizer
TUDCA (tauroursodeoxycholic acid) at 250-500mg supports bile flow, which helps the body process and absorb fat-soluble compounds in the same formula. It also works through its own pathway — reducing endoplasmic reticulum stress in hepatocytes and supporting mitochondrial function.
Three-Layer Detox Support Framework
Rather than dumping every liver-related ingredient into one blend, we structure formulations around the liver's actual detoxification biology:
Phase I — Direct Antioxidant Defense
The liver's first line of defense against toxins is neutralization through antioxidant activity.
Ingredient | Mechanism | Effective Dose Range |
Silymarin (phytosome preferred) | Activates Nrf2 pathway → increases SOD and catalase expression; directly scavenges ROS | 420-600mg/day standard; 160-320mg phytosome |
NAC (N-Acetyl Cysteine) | Precursor to glutathione synthesis; replenishes hepatic GSH stores | 300-600mg/day |
Alpha-Lipoic Acid | Regenerates oxidized vitamins C and E; chelates heavy metals | 100-300mg/day |
Phase II — Conjugation & Elimination Support
Phase II detoxification involves conjugation reactions that make toxins water-soluble so they can be excreted.
Ingredient | Mechanism | Effective Dose Range |
TUDCA | Water-soluble bile acid; reduces hydrophobic bile acid toxicity; supports ER stress resolution | 250-500mg/day |
Reduced Glutathione | Direct conjugation substrate for Phase II reactions | 250-500mg (enteric-protected) |
Milk Thistle | Supports glutathione production; stabilizes hepatocyte membranes | 140-420mg standard extract |
Phase III — Bile Flow & Digestive Support
Phase III is about moving processed toxins out of the liver and into elimination pathways.
Ingredient | Mechanism | Effective Dose Range |
Artichoke Leaf Extract | Stimulates bile production (choleretic effect); supports fat digestion | 300-640mg/day (standardized to cynarin) |
Dandelion Root | Mild choleretic; supports digestive function | 500-2000mg/day (root extract) |
Turmeric Extract | Activates AMPK → promotes fatty acid oxidation; anti-inflammatory via NF-κB downregulation | 500-1500mg/day (phytosomal or with piperine) |
This framework gives your brand a scientifically grounded story — not just a long ingredient list.
Us vs. Market: Formulation Comparison
Dimension | Typical Market Approach | Our Approach |
Ingredient count | 15-25 per formula, often under-dosed | 8-12 targeted ingredients at clinically relevant doses |
Silymarin form | Standard 80% extract (bioavailability ~0.45%) | Phytosome-grade option available (up to 10x absorption) |
Glutathione | Standard oral GSH (destroyed in gut) | Reduced GSH + enteric protection option |
Ingredient logic | Stack everything, hope for synergy | Three-layer framework aligned with liver detox biology |
Curcumin | Standard extract (minimal absorption) | Phytosomal or piperine-enhanced options |
Dosing transparency | Many ingredients at "fairy dust" levels | Every ingredient at or near clinically studied doses |
Testing | Single finished-product test | Three-stage: raw material → in-process → finished product |
Certifications | GMP only | ISO9001/22000, FSSC22000, GMP, FDA, HALAL, REACH, ECOCERT |
Target Market Applications
Segment | Positioning | Recommended Formula Focus |
Premium wellness brands | Daily liver maintenance, clean label | Silymarin phytosome + NAC + Artichoke; 3-4 core ingredients |
Active lifestyle / sports | Recovery, toxin clearance, performance | NAC + ALA + TUDCA + Curcumin; antioxidant focus |
Alcohol / social lifestyle | Hangover support, liver protection | NAC + DHM (dihydromyricetin) + Milk Thistle + B-vitamins |
Metabolic health | Liver fat management, metabolic support | Silymarin + Curcumin + Berberine + Artichoke; AMPK activation focus |
Comprehensive detox | Full-spectrum liver support | Three-layer formula covering all phases |
Quality & Compliance
Manufacturing Standards:
- GMP certified (D-grade, 100,000-class clean room)
- ISO9001, ISO22000, FSSC22000 quality management systems
- FDA-registered facility
- HALAL, REACH, ECOCERT certified
Testing Protocol:
- Raw material identity and potency verification (HPLC, UV, GC)
- In-process controls during blending, encapsulation, and packaging
- Finished product testing: identity, potency, heavy metals, microbials, residual solvents
- Third-party lab verification available upon request
Compliance Support:
- We formulate according to target market regulations (US DSHEA, EU Novel Food, ASEAN TCM, etc.)
- Label review and claim substantiation support
- Stability study data available for registration dossiers
Frequently Asked Questions
Q: What's the difference between standard milk thistle extract and phytosome-grade silymarin?
A: Standard milk thistle extract (typically 80% silymarin) has very low oral bioavailability — about 0.45% for silybin, the most active component. Phytosome-grade silymarin is bound to phosphatidylcholine, which creates a lipid-compatible complex that crosses cell membranes far more efficiently. Research shows phytosomal silymarin achieves up to 10x higher absorption. For premium liver detox products, we recommend phytosome-grade as the differentiator.
Q: Can you make a formula with glutathione that actually works?
A: Oral glutathione is challenging because intestinal enzymes break it down before absorption. We offer two solutions: (1) Reduced L-glutathione with enteric coating to bypass gastric degradation, or (2) a precursor approach using NAC (N-Acetyl Cysteine) at 300-600mg, which provides the building blocks for your body's own glutathione synthesis. The NAC route has stronger clinical evidence and is often more practical for capsule formulations.
Q: What's the minimum order quantity for custom liver detox capsules?
A: Our MOQ is 100,000 capsules. For context, a typical 60-capsule bottle requires about 60 capsules, so MOQ covers approximately 1,667 bottles. We can produce smaller trial batches for formula development and sampling.
Q: How do you ensure ingredient stability in multi-ingredient liver formulas?
A: Multi-ingredient formulas create stability challenges — some ingredients are hygroscopic, others are oxidation-sensitive. We manage this through: controlled-environment manufacturing (temperature and humidity), nitrogen-flushed blending where needed, moisture-barrier packaging options (aluminum blister, amber glass bottles with desiccant), and accelerated stability testing (40°C/75% RH for 6 months) before release. Shelf life is typically 24-36 months depending on the formula.
Q: Can you help with regulatory compliance for different markets?
A: Yes. We have experience formulating for US (DSHEA), EU (Novel Food / Food Supplements Directive), Southeast Asia, Middle East, and other markets. Each region has different rules about which ingredients are permitted, maximum doses, and label claims. We review your target market requirements during formulation development and provide documentation for registration where needed.
Q: What's the typical lead time for production?
A: Sample development takes 7-10 working days. Bulk production takes 15-25 working days after sample approval, depending on order volume and packaging complexity.
Ready to Start Your Liver Detox Product?
Contact us today to discuss your formulation requirements. Whether you need a premium phytosome-based formula or a cost-effective daily support blend, our team will design a solution that fits your brand positioning and target market.
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FAQ
Q
Can you customize product formulations based on cross-border market demands?
A
Absolutely, we can tailor product formulations to meet local consumer preferences and regulatory requirements in your target markets.
Q
Can you provide multilingual labeling and instructions for cross-border products?
A
Certainly, we offer multilingual labeling and instructions to ensure accurate communication of product information in different countries' markets.
Q
What is the MOQ for cross-border business?
A
Our cross-border business MOQ is low, typically ranging from 1000 to 5000 units of products, and can be flexibly adjusted based on specific circumstances.
Q
Can you directly ship to overseas warehouses or facilitate split shipments?
A
We support direct delivery to overseas warehouses and can arrange split shipments according to your needs. We have well-established global logistics solutions.
Q
Do you support commonly used payment methods for cross-border markets?
A
Yes, we support widely used cross-border payment settlement methods such as PayPal, credit cards, and TT bank transfers.
Q
Can you provide import customs clearance documents for major countries?
A
Yes, we can provide customs registration information, inspection reports, and other customs clearance documents for different countries.
Q
Does your product packaging design comply with regulatory requirements in major countries?
A
Our product packaging design can be adjusted to meet the regulatory standards and requirements of different countries, ensuring compliance with local norms.
Q
Can you conduct small-scale production for cross-border testing?
A
Certainly,we welcome small-scale trial orders. We have dedicated small-scale production lines available for cross-border market testing,assisting you in evaluating market potential and feedback.
Tel: +86-537-6728868
E-Mail: chairman@sdrxsw.com
WhatsApp/Wetchat: +86 13562721377
Add: No.8 Wucun Industrial Park, Qufu,Shandong,China. 273100